抄録
This part of the present series of work deals with the immunological studies on the experimental mumps. Previously, the authors described the clinical and hematological aspects of the experimental mumps induced by the strain of virus isolated by the authors. In the present work, the authors determined the hemagglutination inhibition titres (H. I. T.) and the complement fixation titres (C. F. T.) of the sera collected from the volunteers.
Ten volunteers received active virus and 3 received the virus inactivated by the ultraviolet irradiation. Antibody formation was recognized in 8 out of the 10 volunteers who recieved active virus, Fourteen household inmates of the volunteers manifested no clinical signs, and none of them showed the rise in the H. I. T.
As the antigen for these serological tests, Showa B strain, which was used for the infection, and Lederle Mumps Diagnostic Antigen were employed. Needless to say, the antibody formation as measured by the hemagglutination inhibition and complement fixation tests was higher in those demonstrated eminent clinical signs, but even in some of those demonstrated no clinical signs, antibody formation was noted though lower in grade. The presence of the antibody was proved along the progress of the disease. However, its remarkable rise was found closely related to the time of the swelling of parotid gland. In other words, when the swelling of the parotid gland occurred earlier, the antibody formation was found earlier. The timely difference in the rise of H. I. T, and the C. F. T. will he dealt with in separate paper.
