血清, レシチン処理日本脳炎ウィルスのマウスに於ける感染実験の病理組織学的研究

抄録

When rabbits under different conditions were inoculated with Japanese B encephalitis virus, biologically and histologically different findings were observed indicating that certain difference had been cuased by the above conditions. The author selected rabbit serum and lecitin, which is one of the components of the living tissues, particularly of the brain, not possessing any immune body or toxicity. The virus was treated with each of the two substances and inoculated into mouse brains, and they were biologically and histologically observed. The following results were thus obtained.
When Japanese B encephalitis virus treated with rabbit serum was inoculated intracerebrally into mice, no remarkable delay in the manifestation was noted. When the virus was treated with 1%—20 %lecitin, the virus treated with 10% lecitin demonstrated the most delayed manifestation, and that treated with 1% lecitin demonstrated the mildest delay.
The circulation arrest, degeneration of nerve cells, and proliferation and infiltration of round cells in the brain were mils in the cases in which the manifestation was delayed, and were stronger in the cases in which the manifestation was accelerated.
The above facts led the author to believe that the virus had been affected biologically by lecitin thereby milder histological damages of the brain was caused as a morphological indication of the variation of the virus.