放射線に依る皮膚障碍の化学的防禦に就て

特にチステアミン, パントテン酸の臨床應用に就て

抄録

In order to seek a chemical protection against the skin damge, which is one of the limiting factors to the radiation therapy of malignant tumor, cycteamine, pantothenic acid etc. were tried out with rabbits and human cases of breast cancer under postoperative therapy. The following results were thus obtained.
When observed from the skin erosion, the pae- or post-irradiation administration of pantothenic acid failed to allow to increase the radiation dose. Combined application with cysteamine did not increase the effectiveness of panthenic acid. However, the administration of 0.1%—1% solution of panthenic acid was found effective to cure tee skin erosion within 1 month from the termination of irradiation (8, 000-9, 000r), while the control irradiation (8, 000r) caused skin erosion uncurable for along period of time. In the clinical cases, pre-irradiation administration of 10^-3 M cysteamine (combined with pantothenic acid) allowed 1.5 times as large irradiotion dose as the control (5.000r), but the administration of 10-4 M was found inefiectve. Its principal action was considered to be compatition. The application of 2% pantothenic acid carbowax ointment for the treatment of the erosion ameliorated the complaint of the patient, and was found effective to cure it within a period of 11 days when applied 3 times daily or more.