抄録
The influence of nicotine upon the heart of mouse has been studied histopathologically. One half, 1.0, 2.0, 3.0, 5.0, and 7.0 mg/kg of nicotine dissolved in either water or oil were administered to young mice subcutaneously.
Granular degeneration, vacuolar degeneration, swelling, hyaline degeneration, homogenization, histological injury, loosening of vascular wall, blown appearance and zigzagging and disappearance of argetaffine fibers of the interstitial tissue and perimysium were observed.
Hydropic changes appeared in water solution group rather frequently in cases of 0.5 and 1.0 mg/kg administration while the most in 3.0 mg/kg. In oil solution group the parallel relationship was seen between the degree of pathologic changes and the given doses.
Vacuolar degeneration, blown up appearance, histological injury, acceleration of diffusion of blood vessels in the interstitial tissue, blown up appearance, zigzagging and disappearance of argetaffine fibers of the perimysium were observed as morphologic expressien of hychopic lesions.
When the toxicity of nicotine classified histopathogenitically, granular degeneration and homogenization are considered as the secondary direct type, while the hydropic lesions of the perimysium and vacuolar degeneration, blown up appearance and histologic injury of the heart muscle fibers as the secondary indirect type.
