A pharmacological investigation was made on S-benzoylthiamine O-monophosphate (BTMP) and stated in the following are the results obtained thereof.
Mice received and intravenous injection of BTMP in a dose of 2, 000 mg/kg showed acute intoxication and its LD50 was found to be 2, 450 mg/kg. Namely, its toxicity is quite low.
Likewise vitamin B1, there is a temporary lowering of the blood pressure in the rabbits received BTMP, but the elevation of the blood pressure which follows the injection of vitamin B1 does not occur in the case of BTMP. Administration of BTMP increases the amplitude of cardiacc pulse, dilates coronary vessels and promotes respiration. BTMP causes contraction of the ear vessels of the rabbit, while the hind leg blood vessels of the toad dilate when the concentration is low and contract when the concentration is high.
BTMP enhances the hypertensive effect of adrenaline on the rabbit, but it antagonizes the contractive effect of adrenaline on the hind leg vessels of the toad. And, moreover, it shows no influence on the effect of acetylcholine:
BTMP promotes the motility of the smooth muscle organs (extirpated intestine and uterus of the rabbit) .
