四塩化炭素負荷ラットの臓器還元Glutathioneに及ぼすGlucuronic acidの影響

抄録

Following the administration of CCl₄ on rats, or simultaneously, sodium glucuronate (Sod G) or glucuronolactone (GL) was administered on the same rats in order to know their influence on the glutathione (GSH) reduced by CCl₄.
Following the successive subcutaneous injections of CCl₄, the concentration of GSH in the blood, cerebrum and the liver showed a gradual increase. Successive administration of Sod G or GL after the administration of CCl₄ could inhibit this increase in the concentration of GSH.
Subcutaneous injections of CCl₄ repeated every other day produced the elevation of GSH concentration in the blood and the liver, and the combined administration of Sod G and GL could inhibit this elevation of GSH concentration.
Thus, from the standpoint of GSH metabolism, it was found that glucuronic acid influences on CCl₄ and that Sod G and GL are different in the intensity of their influence depending on the organs examined and the method of their administration.