2-methyl-4-amino-5-hydroxymethyl pyrimidine (OMP) およびGlucuronic acid誘導体の臓器Glutathioneにおよぼす影響

抄録

Rats received the administration of 2-methyl-4-amino-5-hydroxymethyl-pyrimidine (OMP) and the derivatives of glucuronic acid for the observation of the changes produced in the glutathione contents of the blood as well as various organs.
1. Subcutaneous injection of OMP produced an evident elevation of the reduced glutathione GSH in the cerebrum, but this elevation was inhibited by the simultaneous administration of pyridoxine (VB₆) . Administration of OMP produced no appreciable changes in the blood GSH concentration, but the GSH concentration of the kidney and the liver showed a lowering tendency several hours after its administration.
2. A single time intraperitoneal injection of sodium glucuronate (Sod G) and glucuronolactone (GL) generally produced the lowering in the GSH concentration of the cerebrum and the kidney. While, the GSH concentration of the liver showed an elevation 24 hours after administration in either case.
3. Successive intraperitoneal injections of Sod G produced the elevation in the GSH concentration of the cerebrum, the kidney and the liver. Whereas, in the case of successive administration made with GL, though there was a slight elevation in the GSH concentration of the kidney, no appreciable changes were recognized on the cerebrum and the blood and the liver showed a tendency of mild lowering instead.