ヒスタミンおよびパラチオン投与マウスの舌腺 (Weber腺) の病理形態学的変化ならびにその比較検討

抄録

Histopathological changes of histamine and parathion intoxication were compared employing the mice which had shown a survival period of approximately 30 days. Mortality rate of the groups received histamine 1-25 mg/kg was 20-30 %, while it showed only but a slight elevation in spite of the administration of 50 mg/kg. On the other hand, the mortality rate of the groups received parathion 2-4 mg/kg was 26.6-31.2%, while it became 73.3% by the administration 8 mg/kg, 80% by 16 mg/kg and 93.3% by 24 mg/kg evidently demonstrating its high toxicity.
Degenerative changes characterized by the mucoid degeneration of glandular epithelium, fusing changes of the cell membrane, degeneration of the adjacent basal membrane, tissue trauma etc, as seen in both experiments No. 1 and No. 2, are indicating the formation of cyst by the fusion of glandular ducts. These changes, however, were more remarkable in the groups admini-stered of parathion. In the groups administered of parathion, moreover, there were interstitial vascular damages and hydropic changes produced by circulatory disturbances indicating the difference in the mechanism of the production of lesions between the two experimental groups.
Proliferation of reservel cells was recognized in the part of regenerated glandular epithelium stimulating further regeneration of the epithelial cells. Histological changes observed in the lingual gland of both histamine and parathion administered mice are considered to be due to the hypoximic effect caused by the chemicals.
Changes observed in the glandular tissues of the mice administered of histamine are mainly those of secondary and direct type, while those of the mice administered of parathion, in addition to the secondary and direct type changes, are produced by the participation of indirect type changes.