低酸素血症性影響を主とした腎硬化性変化に関する病理形態学的研究

抄録

Sodium nitrite and naphthalin, both of which are known as methemoglobin forming poisons, are administered on rabbits by injection in a daily dose of 40 mg, 60 mg, 80 mg/kg for the former and 0.1g, 0.3g and 1.0g/kg for the latter, and the influence of anoxemia and hypoxemia thus produced on the kidney was studied by the pato-morphological investigations of the lesions observed in a short term administration group and a long term administration group.
In the group administered of sodium nitrite, the changes charrcterized by circulatory disturbance such as arterial and venous congestion and edema were remarkable, while the swelling, decomposition and fusing of glomeruli, degenerative and necrotic changes in the tubular epitherium were moderate. In the group of long term administration, futher, sclerotic changes were dominant and there were observed the prolof eration, tear and collagenization of the vascular elastic fibers.
In the group administered of naphthalin, the degenerative and tissue traumatic changes in the tubular epithelium were remarkable in addition to the changes of circulatory disturbance in the stroma. In the group of long term administration, further, the glomerular stroma was hydropic accompanied by mild fibrosis and hyalinization. Reticular fibers of Bowman's capsule and tubular basal membrane were found to have proliferated showing marked bifurcation and tear. Cellular infiltration and fibrosis were recongnized in the stroma, and vascular walls were found to have swollen showing proliferation, degeneration and atrophy of the elastic fibers.
On investigating the morphlogical changes produced in the kidney, it was found first thatt there occur the circulatory disturbance due to the changes produced in blood components and, at the same time, an increase in the vascular permeability due to the hypoxemic influence and the resultant functional distrubance inviting the development of hydropic changes in the pen-vascular region. On the other hand, epithelial cells were found to uneergo degeneration and necrosis by the hypoxemic influence caused by the changes produced in blood components together with the disturbance of intracellular oxidation. As for the hydropic changes produced in the peri-vascular region, in addition to its intrinsic hydroscopic screlosis, there occurred the proliferation of reticular fibers and collagen fibers as repair reaction advancing into collagenization and inviting tissue sclerotic changes. Vasculosclerotic changes, moreover, is considered to further impair blood circulation enhancing hypoxemic state of the kidney, and the development of renosclerotic changes.