Abstract
Intraperitoneal hyperthermic irrigation (IHI) has been developed as a thermotherapeutic procedure for disseminated peritoneal metastasis of cancer. The influence and effect of IHI were studied by experiments on dogs. After laparotomy, the peritoneum was maintaied at 42-44°C for 40 min with 50-55°C saline. Cardiac parameters and arterial blood gases were examined. The pulmonary arterial temperature (PAT) reached 41.2±0.8°C, and increase of pulmonary arterial pressure, cardiac output, and decrease of PaO2 and base excess were significant. All returned to normal after termination of heating. Clinical attemts were made on 22 cases of advanced disseminated cancer. After laparotomy, the peritoneum was kept at 43-45°C for 40-60 min by repeated pouring-shaking-agitating with 10, 000-30, 000 ml of 50-55°C saline. PAT rose to 39.7±0.7°C. Cardiac output increased 35 %, but returned after the end of the heating. No other significant changes were noted. Improvement in symptoms and performance status were found. Survival time was 1-23 months, averaging 5.7. The influence of broad heating of the peritoneum by IHI is similar to that of total-body hyperthermia. With closely controled temperature, changes are slight and reversible. IHI can be performed easily, safely and practically for disseminated peritoneal metastasis of cancer.
