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Volume 50 (1990)
- Issue 6 Pages 585-
- Issue 5 Pages 463-
- Issue 4 Pages 361-
- Issue 3 Pages 219-
- Issue 2 Pages 115-
- Issue 1 Pages 3-
Volume 50, Issue 4
Displaying 1-14 of 14 articles from this issue
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—A HISTOPATHOLOGICAL STUDY OF 84 ANATOMICAL AND BIOPTIC CASES—Katsuhiko HOSONO1990 Volume 50 Issue 4 Pages 361-367
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe relations between alcohol induced hepatic and pancreatic injury were studied on anatomical and bioptic materials registered in the 1 st department of pathology. Eighty-four patients with alcohol abuse, excepting cases of transfusion, HB virus (+), prescribed steroid hormones, diatebes mellitus, cholelithiasis were clinically or histo-pathologically examined. Hepatic injury was classified into six types including hepatocellular carcinoma, liver cirrhosis, severe fibrosis, alcoholic hepatitis and fatty liver. Pancreatic injury was classified, according to Tanaka's classification in which to the fibrosis of intra or inter lober space in pancreas was determined. Hepatic injury, especialy liver cirrhosis and severe fibrosis paralleled panreatic injury from a standpoint of fibrosis in the early or middle stage. Hepatocellular carcinoma unlike pancreatic fibrosis, showed dissociation from pancreatic fibrous change. Chronic pancreatitis (severe fibrosis) showed dissociation from hepatocellular carcinoma and liver cirrhosis.View full abstractDownload PDF (5491K) -
Minoru YOSHIDA1990 Volume 50 Issue 4 Pages 368-381
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSEvaluation of the severity of hone atrophy was attempted using the microdensitometry/multiple scanning (MD/MS) method to determine the morbidity of osteoporosis. To study quantitative and qualitative changes occurring in osteocalcin (OC), pure OC was refined by a new method with a good yield. The subjects were 75 cases of osteoporosis. Severity was determined by the MD/MS method, and the images obtained were evaluated according to Jikei's classfication by dividing them into 4 categories. Relations of blood Ca, P and AI-p with bone densities determined by the MD and MD/MS methods were investigated by measuring OC in blood. The method of Price et al. was modified by use of the femoral cortical bones in cattle and man, and OC was refined by high-pressure liquid chromatography (HPLC) . Result of studies suggest that the MD/MS method is useful as an index for evaluating osteoporosis, since classification by the MD/MS method correlates with Jikei's classification. Bone density tends to remain if OC is maintained, and the MD/MS method shows blood OC increasing in reaction to the decrease in bone density. This suggests that OC participates in bone formation. It has thus become possible to extract OC efficiently and simply, from which it is presumed that the new method will be useful in the future for determining the presence or absence of qualitative changes of OC.View full abstractDownload PDF (5389K) -
—WITH REFERENCE TO ECHOGRAPHIC PICTURES OF INTERNAL GLANDS—Kazuyuki TAZAWA, Toshiichi KATAOKA, Yutaka SIBASAKI, Toyohiko SAITO, K ...1990 Volume 50 Issue 4 Pages 382-389
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSRecent improvements in ultrasonographic instruments have enabled us to estimate differences in echographic patterns of prostatic hypertrophy. We recently compared histopathologic findings with echographic pictures of hypertrophic prostate glands obtained at autopsy in an attempt to classify ultrasonographic patterns. Sixty-one cases of prostatic hypertrophy with no other urological disease were studied. After fixing the bladder, rectum, urethra and prostate in the same positions found in the body, we performed horizontal tomography using spectral chair-type (Aloka SSD-520, 5.0 MHz and 7.0 MHz), transrectal ultrasonographic equipment. The histopathological findings were estimated from specimens cut at the same level as the ultrasonogram. Based on the pathological findings, these adenomas were classified into three types : glandular (23 cases), fibromyomatous (18 cases) and mixed (20 cases) . In the glandular type, which consisted mostly of well developed glandular legions, hypoechoic pictures were found in the ultrasonogram. The fibromyomatous lesions, where fibromyomatous tissue was the main component and glandular tissue was sparse, showed hyperechoic pictures in the echograms. Both hyperechoic and hypoechoic patterns were observed in most areas of the mixed type of prostatic hypertrophy. Characteristic echographic patterns for each histopathologic type of hypertrophic prostate were observed in 17 cases (73.9%) of the glandular type, 13 cases (72.7%) of the fibromyomatous type and 14 cases (70.0%) of mixed type. Clear classification of the ultrasonographic pictures into three patterns was difficult in some cases, because of inflamation, stones, etc.View full abstractDownload PDF (4941K) -
Keiichi OHTA, Yoshio HIGAKI, Kazuo IMAMURA1990 Volume 50 Issue 4 Pages 390-394
Published: August 28, 1990
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSThe authors studied the pretreatment and post-treatment levels of PAP, γ-Sm and PA in 44 cases of prostatic carcinoma diagnosed on the basis of biopsy and treated between June 1983 and August 1988 at our institution. These parameters were also measured during follow up in an attempt to determine if they were significant in evaluating therapy, based on criteria which we developed to determine clinical effects in cases of prostatic carcinoma. In low stage cases, such as stages A and B, there was no difference in these parameters among improved, unchanged and progressive disease cases. In stage C there was significant decrease in all three parameters in the improved and unchanged groups, but there was no significant change in the progressive disease group. In stage D cases, a significant decrease was recognized in all three parameters in the improvment group, but because of the small number of cases the unchanged and progressive disease group cases could not be evaluated. Cases were also divided into those with normal pretreament PAP, γ-Sm and PA values and those with abnormal pretreatment values. In the former group no significant change was observed in any of the improved, unchanged and progressive disease groups. Among the cases with abnormal pretreatment values, significant decrease was seeni n all three parameters in cases showing improvement, whereas in the unchanged group there was significant decrease in PAP and PA. In the progressive disease group there was no significant change in any of the parameters. It was concluded that many low stage cases have low pretreatment values for the above three parameters, and in these cases careful clinical evaluation should be sufficint for observation of the course. In more advanced cases the PAP, γ-Sm and PA values decrease with improvement, suggesting that measurement of these parameters would be useful to evaluate progress.View full abstractDownload PDF (626K) -
Motoki HIRAMORI, Yoshibumi SUGIMURA, Yoshio HIGAKI, Kazuo IMAMURA1990 Volume 50 Issue 4 Pages 395-398
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSGenerally metastatic bone lesions can be recognized roentgenologically as osteolytic changes and these cases can show hypercalcemia. In bone metastasis from prostatic carcinoma it has been reported that osteoplastic findings can be recognized roentgenologically and changes in serum calcium level can also be detected. This suggests that changes in calcium metabolism occur in cases of prostatic carcinoma with bone metastasis. To clarify this, calcium regulating hormone was studied in cases of prostatic carcinoma. The cases studied were 12 cases definitively diagnosed histopathologically on the basis of biopsies between January 1985 and December 1986. Of these, 13 were in stage A or B, 14 were in stage C and 5 were in stage D. The average age was 75.0 years. Control cases were 8 contemporary cases of prostatic hypertrophy treated at the same time and also diagnosed histopathologically. Cases with any metabolism related disease such as hepatic dysfunction or diabetes were excluded. The parameters studied were: blood 1α, 25 (OH) 2D (by RRA), PTH-M (by RIA), Ca (by OCPC), P (by molybdenic acid tintometry), alkaline phosphatase (by PNP) . Results showed no significant difference between hypertrophy and stage A, B or C prostatic carcinoma, but stage D cases with metastatic bone lesions showed lower serum calcium lower 1 α, 25 (OH) 2D, and higher PTH-M. These results show that prostatic carcinoma accompanied by bone metastasis reveals abnormal calcium metabolism.View full abstractDownload PDF (375K) -
Hiroshi KUSHIRO, Kazushige ARAI, Tadashi KOIKE1990 Volume 50 Issue 4 Pages 399-409
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIntraperitoneal hyperthermic irrigation (IHI) has been developed as a thermotherapeutic procedure for disseminated peritoneal metastasis of cancer. The influence and effect of IHI were studied by experiments on dogs. After laparotomy, the peritoneum was maintaied at 42-44°C for 40 min with 50-55°C saline. Cardiac parameters and arterial blood gases were examined. The pulmonary arterial temperature (PAT) reached 41.2±0.8°C, and increase of pulmonary arterial pressure, cardiac output, and decrease of PaO2 and base excess were significant. All returned to normal after termination of heating. Clinical attemts were made on 22 cases of advanced disseminated cancer. After laparotomy, the peritoneum was kept at 43-45°C for 40-60 min by repeated pouring-shaking-agitating with 10, 000-30, 000 ml of 50-55°C saline. PAT rose to 39.7±0.7°C. Cardiac output increased 35 %, but returned after the end of the heating. No other significant changes were noted. Improvement in symptoms and performance status were found. Survival time was 1-23 months, averaging 5.7. The influence of broad heating of the peritoneum by IHI is similar to that of total-body hyperthermia. With closely controled temperature, changes are slight and reversible. IHI can be performed easily, safely and practically for disseminated peritoneal metastasis of cancer.View full abstractDownload PDF (1378K) -
Sohtarou KANNO1990 Volume 50 Issue 4 Pages 410-416
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAnticancer effects was studied in a cell line (OHR) established from human non-a-fetoprotein (AFP) producing hepatoblastoma. In vitro tests for sensitivity were examined by MTT assay, 3H-Thymidine (TdR) uptake test, and Human Tumor Clonogenic Assay (HTCA) . The culture cell line were dosed with Adriamycin (ADM), Vincristine (VCR), Mitomycin-C (MMC), Cisplatin (CDDP) and 5-fluorouracil (5FU) . The results of each test for sensitivity were: 1) With the MTT assay, all the agents were dose-dependent. ADM, VCR, MMC and 5FU were time-dependent as well, but CDDP was not. The Cytotoxicity Index of ADM, VCR and 5FU were 60 % or more. 2) In the 3H-TdR uptake test, all agents were dose-dependent. The cytostatic effect of ADM was particularly high with low concentration. The Inhibition Index of ADM, MMC and 5FU were 60% or more. 3) The inhibiting rates of colony-formation of ADM and 5FU were less than 60 %, and no inhibiting effect was found in CDDP. This study demonstrated that ADM, VCR and 5FU have cytostatic effects for this cell line.View full abstractDownload PDF (860K) -
Satoshi NAKAJIMA1990 Volume 50 Issue 4 Pages 417-424
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSMyofibrous organization of the thyrohyoid (TH) muscle from nine female fur-seals was analyzed and compared with that of other vertebrates including man. Hematoxylin eosin (HE) stained sections and Sudan Black B (SBB) stained sections were analyzed. Results: 1. Myofibrous organization of HE stained sections of seal TH muscle tended to be similar to the human mylohyoid muscle. This suggests that the TH muscle of the seals is well developed. 2. The cross sectional area of the muscle belly of seal TH muscle was larger and there were more muscle fibers than in any SBB stained suprahyoid muscles of the crab-eating macaques compared. The thickness and number of muscle fibers in a 1 mm2 block were similar to those in the mylohyoid and the anterior belly of the digastric, which were the largest of the macaque suprahyoid muscles. The density was greater than any of the macaque muscles compared. The proportion of white muscle fiber was greater in the TH than in any of the muscles compared. The thickness of white muscle fiber was similar to that of the mylohyoid and anterior belly of the digastric, and was remarkably larger than those of any other muscles compared. 3. The following results were obtained from comparison with the constrictor pharyngis inferior (CPI) muscle. Although the cress sectional area of the TH muscle belly was smaller than that of the CPI muscle of the fur-seals from the same sample stock, the density of TH muscle was greater than that of the CPI muscle. The three fiber types in TH muscles occurred with frequency similar to those in the seal CPI muscles. The thickness of each fiber type in TH muscles was larger than those in CPI muscles. The thickness of white muscle fiber of seal TH muscles was larger than those of human CPI muscles and the density of seal TH muscle was greater than that of the human CPI muscles. 4. Analysis of the ages of the samples revealed that the seals were in the developing stage (during their first 3 years) by the number and size of the muscle fibers.View full abstractDownload PDF (865K) -
Katsuhiko HOSONO, Tatsuro KUROKI, Kazuhiko SOEJIMA, Mikio KANDA, Tatsu ...1990 Volume 50 Issue 4 Pages 425-431
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSPulmonary fibrosis is a terminal productive phase. Pulmonary fibrosis occurs in inflammation scars and in emphysema of the lung. It is a proliferation of collagen fiber as a result of increase of fibroblasts. Myofibroblasts and collagen type III constitute the proliferative linkage. Collagen type III turns into collagen type I in the phase in which fibroblast turns into myofibroblast. Collagen type III is prominent in immature connective tissue. Collagen type I is prominent in mature conncetive tissue. We studied changes of the bronchus by light microscopy, electron microscopy and immunohistochemistry, especially the fibrosis of mucous membrane of the bronchus, the basement membrane, the peribronchial area and smooth muscle of the bronchus, after inhalation of antigen. Immunohistochemistry was used with anti-collagen type III monoclonal antibody, anti-laminin polyclonal antibody, anti-fibronectin polyclonal antibody and anti-smooth muscle monoclonal antibody. In the early phase of fibrosis of the bronchial wall, anti-collagen type III monoclonal antibody increased sensitivity in the subepithelial lesion of the bronchus and in the perimuscular connective tissue of the bronchus. Electron microscopy proved that fibroblasts and myofibroblasts were in the same lesions of the bronchus. Fibrosis of the bronchial lesion is gradually accelarated by an attack of asthma, except inflammation.View full abstractDownload PDF (3976K) -
Kimio NAMATAME, Tadaaki IKEDA, Hiroko IWAI, Mikio MAKUUCHI, Masahiko O ...1990 Volume 50 Issue 4 Pages 432-437
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESS46 cases of pm cancer (gastric cancer with invasion into the proper muscle layer) diagnosed by macroscopic appearance, at our hospital between 1975 and 1983 were examined clinicopathologically. The results were: 1. pm cancer in 13.9 % of all cases of resection. Macroscopically, the Borrmann type comprised 69.6 % of pm cancer, more frequent than the early advanced type (30.4 %) . The mean age was 54.8 years. pm cancer affected males most often. 2. Most pm cancer was located in the A area. There was no difference in location of the early advanced type and the Borrmann type. The Borrmann type 1 cancer, however, was often located in the C area. 3. The pm cancer was usually larger than 2.0 cm in diameter. The rate of lymph node metastases was 41.3 %, and there was no difference among the macroscopic types. On the Borrmann type cancer cases, 6.5 % were n2 positive. 4. Lymphatic invasion was often observed in pm gastric cancer (84.8 %), and severe lymphatic invasion to ly2 or ly3 was seen, particularly in the Borrmann type. Venous invasion was observed in 17.4 % of the Borrmann type cancer. 5. Histologically, the differentiated type accounted for most of the pm gastric cancer, both Borrmann type 1 and Borrmann type 2. Borrmann type 3 cancer accounted for most of the undifferentiated type. There were no differences between the differentiated and the undifferentiated types in lymph node metastasis.View full abstractDownload PDF (649K) -
Kouichi INOUE, Kouichirou YAMADA, Akira ISHIKAWA1990 Volume 50 Issue 4 Pages 438-444
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA statistical analysis was made of patients in the City of Yokohama who visited our clinic for urinary screening tests (stage III by the regulation of Ministry of Education) between June 1985 and Nobember 1989. Among 420 patients (156 males, 264 females) studied, 312 (110 males, 202 females) had abnormal urine findings for the first time. Among them, 141 patients (45.2 %) were diagnosed as having asymptomatic hematuria. Thirty two percent of the patients who were diagnosed in 1985 as those with asymptomatic hematuria were cured or improved within five years, and 23 % who were diagnosed in 1986 were cured or improved within four years.
However, about half of all patients did not return for the follow up study. It is important to find the patients with genitourinary abnormarities in the early stage, and adequate follow up study should be developed.View full abstractDownload PDF (700K) -
Hiroshi KUSHIRO, Takao OKAMATSU, Masashi YATSUZUKA, Yuhko TSUNODA, Shi ...1990 Volume 50 Issue 4 Pages 445-449
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWhen the presence of a retained foreign body induces risk, removal of the foreign body is necessary. In the past, endoscopic or surgical removal have been preferred. In Japan, Ito reported removal of a disk battery by using a magnet tube in 1983. Our experience with 10 patients for 6 years from 1984 to 1989 has also suggested that this tube is safe, effective and rapid for removal of blunt metallic foreign bodies in infants and children. Availability of the magnet tube creats a new option for first aid in the treatment of ingestion.View full abstractDownload PDF (4179K) -
Osaaki KAJITA, Masahito TAIRA, Shoji SAKURAGI, Toru OKUBA, Tomoko SUZU ...1990 Volume 50 Issue 4 Pages 450-456
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe symptoms of this case correspond to presenile dementia accompanying MND, proposed by Mitsuyama as a kind of disease in 1979. As presenile dementia, the symptom was considered to be Pick's disease, which causes disorder mainly in the frontal lobe as determined by clinical symptoms and the image of cranial CT and 123I -IMP SPECT. This case had remarkable personality disorders such as euphoric apathy, and concurrently exhibited symptoms presumed to be Denkfaulheit and stehende Redensarten. However, no triebhafte Enthemmung, peculiar to phase I of Pick's disease, was observed, and it was assessed as comparable to cases usually reported as frontal lobar type Pick's disease from autopsy and 123I -IMP SPECT findings. The course of this case was further complicated by MND for which an attempt was made to clinically differentiate it from demential disease that accompanies MND, and consideration was given to positioning of this disease.View full abstractDownload PDF (4328K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1990 Volume 50 Issue 4 Pages 457-462
Published: August 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (647K)
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