循環系の統合的理解のための細胞・組織・臓器レベル生理学知見集約生体機能モデル

抄録

Circulatory system is a complicated system, which is finely tuned to maintain adequate blood supply to the cells. For the comprehensive understanding of the system, it is necessary to develop integrative models that are based on detailed cell models. Pathologies at the cellular level propagate to the organ and impair cardiac functions. Conversely, failure of the circulatory system harm normal healthy cells and damage the organ function. These mutual interactions could only be understood quantitatively by using multi-scale simulation models. In the presentation, such multi-scale models will be introduced to discuss utility of the models in the field of biomedical engineering for the further investigation of the circulatory system.