Effects of rest insertion combined with whole-body vibration on bone healing in ovariectomized mice

抄録

Whole-body vibration (WBV) promote fracture healing. This study was undertaken to evaluate whether rest insertion into WBV would enhance its therapeutic efficacy. Mice were ovariectomized at 10 weeks of age, and a week later, a full-thickness unicortical hole was created at a tibial diaphysis. On the next day, mice were assigned to three groups: CW, RW, and control, exposed to continuous WBV (30 Hz and 0.3-g amplitude), a consecutive repeat of 3-s WBV bouts followed by 9-s rest, and no WBV, respectively. The WBV treatment was applied for 30 min/day and 5 days/week. Two weeks later, the drilled segment was scanned by synchrotron radiation CT. WBV tended to increase bone volume fraction in the defect with further increase in RW (10.3%) than in CW (5.8%) although the differences were not significant. This data indicates that rest insertion could be effective in combination with a fracture treatment by WBV.