2018 年 Annual56 巻 Abstract 号 p. S374
Diamond-like carbon (DLC) films have many attractive properties including bio/blood-compatibility. On the other hand, Zinc (Zn) is known to enhance bone formation. In order to utilize both features, we developed the Zn-doped DLC (Zn-DLC) films by a sputter deposition technique. In our previous study, we confirmed that the Zn-DLC films released Zn and enhanced osteogenesis of mouse osteoblastic cell line in-vitro (Katouno et al., Diamond and Related Materials, 2017). In this study, we investigated the effect of the Zn-DLC films on healing periods of bone fracture using a mouse model. The fractured legs were fixed with Ti plates with DLC films (DLC/Ti) or Zn-DLC films (Zn-DLC/Ti) until fracture gaps were filled. As a result, the healing periods of DLC/Ti group and Zn-DLC/Ti group were 8 weeks and 4 weeks, respectively. Our preliminary results suggested that Zn-DLC films have a potential of accelerating healing process.
