Paper-based analytical devices for point-of-care tasting with instrument-free detection

抄録

Paper-based analytical devices (PADs), consisting of flow channels surrounded by hydrophobic barriers, are promising in the realization of point-of-care testing outside equipped laboratories because of their portability, easy disposal, and simplicity in fabrication and operation. The conventional detection scheme is colorimetry where color intensity depending on the analyte concentration represents quantitative information. However, colorimetry needs a scanner or a controlled light source for the reproducible image capture, and a personal computer for image processing. Therefore, in addition to colorimetric detection, we have developed several types of PADs using the detection schemes without instrument which are based on zone-counting readout and distance-based readout. We have also explored ways to enhance the sensitivity and to stabilize the reagents deposited on a paper substrate. Here, we overview our achievements in the study of PADs [1].

[1] T. Kaneta, W. Alhamad, P. Varanusupakul, Appl. Spectrosc. Rev., 54, 117-141 (2019). (DOI: 10.1080/05704928.2018.1457045)