てんかん波抑制における冷却速度と脳波帯域の関係

抄録

Focal brain cooling can suppress epileptic discharges (EDs) in the cerebral cortex and also suppress frequency spectral powers in the EDs with temperature-dependent effect. The objective of this paper is to investigate the dependence of the cooling rate on the EDs suppression with experiments using 4 epilepsy model rats. The cortical surface of the rats was cooled to 16^oC, and time condition for brain cooling from initial temperature to 16^oC was set at 30, 60, 100 and 200 sec respectively. Obtained ECoG data were divided for 4 frequency bands (δ(0.5-4Hz), θ(4-8Hz), α(8-13Hz), β(13-30Hz)) to elucidate the effect of change in the frequency band of EDs depending on the cooling rate. The power spectral during cooling of each condition were compared to the power spectral of pure EDs (non-cooling state). Our results demonstrated that the suppression of EDs have a cooling rate dependency, and all of the frequency band in the EDs are smaller when the cooling rate is slower. These findings could contribute to elucidation of the mechanism of suppression EDs.