局所脳冷却がてんかん焦点及び周辺部位の周波数特性に及ぼす影響

抄録

In this study, we examined the suppression effect of brain cooling on the epileptic focus and surrounding area. An epileptic seizure was induced in rats to obtain electrocorticography (ECoG) data when brain cooling was performed on the epileptic focus and its surroundings. Then, the frequency response characteristic was calculated by applying fast Fourier transform (FFT) and band pass filter to the obtained multichannel brain wave data. As a result of comparing the calculated frequency responses for each rat, it was found that at the site where epileptic seizures were observed, power was reduced by cooling and suppressing effect was observed, whereas at the same time, the power increased at the site a few millimeters adjacent to the seizure site was confirmed. This result suggests that epileptic waves suppressed by brain cooling might propagate to the surrounding area by a few millimeters.