抄録
It is said that compliance mismatch between a native vessel and a artificial vascular graft causes low patency after several years of implantation. To develop a vascular scaffold having a mechanical characteristics like native vessels, a bi-layered tubular scaffold composed of a porous CLLA inner layer and PLLA fibrous outer layer using electrospinning technique was fabricated. A porous CLLA scaffold was inserted to mandrel-type collector having larger diameters than inner that of CLLA tubular scaffold and PLLA was electrospun onto a pre-strained porous CLLA scaffold. In this study we researched relationships between wall thickness and each electrospinning conditions and effects of pre-straining on mechanical characteristics of fabricated multi-layered tubular scaffold.
