OS1412 血管を保持した脱細胞担体を用いた子宮組織の再生

抄録

Female infertility and other dysfunction related to the female reproduction cycle are rising problems in today's decreasing population growth. Current research in uterine tissue regeneration focuses towards partial restoration of function through partial regeneration of the uterine tissue, mainly due to the difficulties created by the complex microvascular system in the uterine tissue. Certain dysfunctions however will require a full organ transplant which is currently difficult to obtain. Previous works have shown the viability of high hydrostatic pressure in uterine tissue regeneration (E. G Santoso, Keita Yoshida, et. al., PLOS One, 2014) and the possibility of whole uterine recellularization with the use of the microvascular network (Kaoru Miyazaki, Tetsuyo Maruyama, Biomaterials, 2014). In this research we used a new method in recellularization of the decellularized uterine tissue with the use of microvasculature network assisted cell inoculation and culture.