S021013 ヒト脳動脈瘤の組織変性プロセスに関与する異常血流の特定に向けて:ブレブ発生・成長と衝突流れの相関([S02101]人工臓器におけるバイオメカニクス(1))

抄録

This study aimed to investigate "malignant hemodynamics" leading to induce the wall degradation of cerebral aneurysms in an effort to find out a reliable predictor as to which aneurysms were doomed to rupture. Two blister-holding aneurysms and two bleb-holding aneurysms were computationally analyzed and compared with those of aneurysmal appearances observed during operations. The results demonstrated that the sites of flow impingement and bifurcation were well correlated with those of blisters. Such a flow pattern was confirmed to be present at the neck of bleb. The inside of bleb was found to be dominated by weak regurgitation as a result of flow bifurcation. The possible scenario for the genesis and growth of bleb was proposed. Flow impingement was concluded to play a malignant role on aneurysmal wall degradation.