肝臓形成と血管新生の数値解析

－小葉と検証－

抄録

Liver is the main organ of metabolism and loss of the function causes death. Liver has high regenerative ability but the mechanism of the formation has not been made clear yet. This is why this research makes the modeling of liver formation with numerical simulation. Then, this research aims to elucidate the mechanism of liver formation. Furthermore, this simulation has possibility to help experiments of regenerative medicine. This research proposes an analysis model by using the particle method as the first step in this study. The analysis object is a hepatic lobule. A purpose of this analysis is to elucidate the process, mechanism, and condition of cell growth in the micro-scale. Restriction of cell survival area by oxygen depletion is the most serious problem in liver cell proliferation technology development. It is necessary to extend the cell survival area by angiogenesis. This research got results which blood vessels formed from portal veins to a central vein, repeating branching and connecting in the whole shape of a liver by using a model of angiogenesis. This is why a hepatic lobule was filled with liver cells. Also, cross sections of the analysis results got the value of rates of the cross sectional area of the blood vessel. This research is going to consider the oxygen content in the blood to enhancing consistency with experiment.