バイオシートを用いた二葉型人工房室弁の開発

抄録

This study aimed to develop a simple artificial atrioventricular valve with bi-cusps using a collagen tissue sheet (Biosheet) obtained by in-body tissue architecture. Because of the longer time required to fabricate Biosheets, we have been investigating the influence of valvular shape on performance by fabricating modelled valves using polyurethane sheets with mechanical properties that match those of the Biosheet and performing an in-vitro flow simulator. Our previous study showed that the regurgitation performance of our designed bicuspid atrioventricular valve prostheses could not be satisfied with clinical criteria. We evaluated the valve performance for our valve model and visualized the flow field around the closing valvular cups using an in-vitro flow simulator simultaneously. The experimental result showed that the geometrical size of our developed atrioventricular valve model did not affect the closing volume of the regurgitant flow and affected the length of the cuspid free edge.