抄録
It is well known that Candida albicans is one of important agents causing opportunistic fungal infection. McCullough et al. showed 4 genotypes in C. albicans (including C. dubliniensis) using 25S rRNA. There are many reports about genotyping of C. albicans in various countries. However this is the first report of genotyping of C. albicans isolated from Xinjiang Uygur Autonomous Region in China. Thirty-nine isolates from 52 HIV/AIDS patients at a hospital in Xinjiang Uygur Autonomous Region were genotyped. At the same time, 100 isolates from non-AIDS patients at a hospital in Tokyo were also genotyped. Results: Uighurian isolates were divided into genotypes A (51%), B (36%) and C (13%), Japanese were A (63%), B (28%) and C (9%). We compared these data with other countries'. The profile of Uighurian was similar to that of Turkish rather than Chinese (Chengdu). It is clear that the genotypes are characteristic in each area (geographical) and ethnic (ethnological). The other hand, we refined on ALTS analysis aiming at identification strain level. Specifically we used μTGGE (micro temperature-gradient gel electrophoresis) instead of agarose gel.
Collaborators: Pu XM2), Erfan A2)
