抄録
Using anti-carbonyl reductase (CR) antibody, immunohistochemical staining was performed on 73 epithelial ovarian cancers and 25 benign ovarian tumors. The combined rate for strongly and weakly positive reactions for CR was 32.0% for benign tumors and 61.6% for ovarian cancers. The CR positive rate was 35.7% for ovarian cancers with retroperitoneal lymph node (RLN) metastasis and 67.8% for those without RLN metastasis, the former being lower than the latter (p<0.05). While the expression of vascular endothelial growth factor (VEGF) and Flt-4 observed by immunoblotting was coincidently altered in the individual cancer samples, the amounts of VEGF and Flt-4 were augmented according to the decrease of CR expression.
