D-Allose Metabolism in Rats

Abstract

D-Allose is one of the aldohexoses present in small quantities in nature. The present study investigated absorption and excretion of D-allose when administered orally (8 g/kg body weight) to eight-week-old Wistar rats. No diarrhea or any other abnormality was observed in rats after D-allose administration. Urinary and fecal excretion of D-allose during the 24 h following oral administration was 90.9 and 2.7% of the dosage, respectively. D-Allose content in the stomach decreased rapidly over 3 h, and little D-allose was found in the small intestine and cecum. These results suggest that D-allose is largely absorbable from the digestive tract into the blood, and then is rapidly excreted into urine.