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Volume 63, Issue 1
Displaying 1-3 of 3 articles from this issue
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Review
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(2009 JSNFS Young Investigator Award)Koji Nagao2010 Volume 63 Issue 1 Pages 3-7
Published: 2010
Released on J-STAGE: March 09, 2010
JOURNAL FREE ACCESSMetabolic syndrome is a cluster of metabolic disorders, including abdominal obesity, dyslipidemia, hypertension and impaired fasting glucose, which contributes to increased cardiovascular morbidity and mortality. Although the pathogenesis of metabolic syndrome is complex, and the precise mechanisms have not been elucidated, dietary lipids have been recognized as contributory factors in the development and prevention of cardiovascular risk clustering. This study explored the physiological functions and molecular actions of functional lipids, such as n-3 polyunsaturated fatty acids, conjugated fatty acids, sterols, and phospholipids, in the development of metabolic syndrome. Dietary functional lipids suppressed the accumulation of abdominal adipose tissue and lipids in the liver and serum, and alleviated hypertension and type 2 diabetes through transcriptional regulation of lipid and glucose metabolism. In particular, the role of functional lipids as dietary adiponectin inducers (dietary insulin sensitizers) deserves attention as a means of alleviating metabolic syndrome by dietary manipulation.View full abstractDownload PDF (851K)
Original Paper
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Osamu Nakagawasai, Hiroshi Onogi, Atsushi Sato, Hiromi Watanabe, Hajim ...2010 Volume 63 Issue 1 Pages 9-16
Published: 2010
Released on J-STAGE: March 09, 2010
JOURNAL FREE ACCESSThe present study investigated whether calcium pantothenate has an anti-fatigue effect and/or is able to ameliorate cognitive deficit in mice. At 1.5 or 3 h after forced walking, mice were assessed for behavioral specificity, locomotor activity and swimming behavior in a forced swimming test, with or without administration of calcium pantothenate. We also examined the effect of calcium pantothenate on scopolamine-induced cognitive deficit using a Y-maze and passive avoidance task. Calcium pantothenate (administered orally at 300 or 600 mg/kg) significantly ameliorated the reduction of locomotor activity and swimming behavior after forced walking for 3 h. Mice that were not administered calcium pantothenate showed a significant reduction of locomotor activity relative to the treated group. However, acute or chronic administration of calcium pantothenate did not ameliorate the cognitive deficit induced by scopolamine in the Y-maze and passive avoidance tests. These results may have important implications in relation to prevention of physical fatigue using calcium pantothenate as a supplement.View full abstractDownload PDF (955K)
Research Paper
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Yusuke Iga, Tatsuhiro Matsuo2010 Volume 63 Issue 1 Pages 17-19
Published: 2010
Released on J-STAGE: March 09, 2010
JOURNAL FREE ACCESSD-Allose is one of the aldohexoses present in small quantities in nature. The present study investigated absorption and excretion of D-allose when administered orally (8 g/kg body weight) to eight-week-old Wistar rats. No diarrhea or any other abnormality was observed in rats after D-allose administration. Urinary and fecal excretion of D-allose during the 24 h following oral administration was 90.9 and 2.7% of the dosage, respectively. D-Allose content in the stomach decreased rapidly over 3 h, and little D-allose was found in the small intestine and cecum. These results suggest that D-allose is largely absorbable from the digestive tract into the blood, and then is rapidly excreted into urine.View full abstractDownload PDF (633K)
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