Abstract
High-density lipoprotein (HDL) exerts an anti-atherogenic effect primarily by facilitating the efflux of cholesterol from macrophages and transporting it back to the liver in a process known as reverse cholesterol transport (RCT) , and thus it is considered to be an anti-atherogenic lipoprotein. We revealed that coffee-derived polyphenol increased the efflux of cholesterol from macrophages via cholesterol transport molecules in vitro. To explore the mechanisms involved, the effects of HDL on RCT function with coffee-derived polyphenol were widely examined in vivo and ex vivo. The findings revealed that food factors exert anti-atherogenic effects by improving HDL function, and not only increasing HDL-C.
