2025 Volume 78 Issue 3 Pages 131-137
Recent advances in our understanding of adipose tissue biology have revealed that adipose tissue is not a simple organ for storing excess energy, as previously thought, but a more complex organ that regulates systemic metabolism through functions such as energy delivery and metabolism in response to changes in energy status as well as adipokine secretion. Since insulin plays a central role in many aspects of the regulation of adipose tissue function, insulin sensitivity in adipose tissue is considered an important factor in the control of systemic metabolism. In this article, we review new insights into the mechanisms of metabolic regulation by white adipocytes that have emerged from recent studies using mice with tissue-specific knockout mice of PDK1 and other insulin signaling molecules.
