Lifestyle-related Disease and Sarcopenia

Abstract

Sarcopenia is characterized by age-related loss of skeletal muscle mass and strength and is closely associated with lifestyle-related diseases such as diabetes, obesity, cardiovascular disease, chronic kidney disease (CKD), and chronic obstructive pulmonary disease (COPD). These diseases promote the development and progression of sarcopenia through insulin resistance, chronic inflammation, and hormonal abnormalities. In recent years, the pathophysiology of sarcopenia has been increasingly clarified, with a particular focus on its interaction with lifestyle-related diseases. This review outlines the relationship between sarcopenia and lifestyle-related diseases and presents evidence for the mechanism.