Effect of Hypocholesterolemic Substance in SHIITAKE on Sterol Metabolism in Rat

Abstract

Effect of hypocholesterolemic substance of SHIITAKE, mushroom Lentinus Edodes, on the cholesterol content of plasma, liver and adrenal, and the excretion of sterol and bile acids was observed.
With feeding of hypercholesterolemic diets containing 7% dried SHIITAKE for 29 days to rats, the experiment showed significant reduction in plasma and adrenal cholesterol, and increase in fecal excretion of bile acids.
With feeding of eritadenine, hypocholesterolemic substance of SHIITAKE, at 8mg% level for one week to the rat, it caused significant reduction in plasma cholesterol, but no significant effect on fecal excretion of bile acids.