Abstract
The subcellular distribution of gold and β-galactosidase activity was studied in livers of mice injected with gold thioglucose (GTG). Mice were divided into four groups: (1) control, (2) mice 2 days after GTG in jection, (3) obese and (4) nonobese mice 15 days after GTG injection. In comparison with the control mice, the liver protein and DNA contents of icer injected with GTG decreased significantly, β-galactosidase activity increased in all organella and cytosol fraction showed higher activity at 2 days after GTG injection. The distribution of both, β-galactosidase and gold differed between obese and nonobese mice. Gold was found mainly in the nuclear (ppt 1, 000 X g) fraction.
