Abstract
Changes in urine flow, urinary sodium and potassium output after saline loading were investigated in Japanese young men. Subjects (32 males, 19-25 yr) drank 500ml of 0.9% saline within 10 minutes after more than 10 hours' overnight fasting and water depletion at room temperature 24±2°C, and 30-60% humidity in November. Blood pressure, urine flow, and urinary sodium and potassium concentrations were measured throughout the experiment; one hour before drinking and consecutive 4 hours after drinking. Obtained data were compared with that of control experiment in which 500ml of water alone was administrated at the same protocol (34 males, 19-25 yr).
Urinary sodium excretion after saline intake, increased two times as much as that before drinking, and kept constant between one and half, and four hours after drinking. The values were significantly higher than that of control experiment. Total urinary output of water, sodium and potassium after saline intake were 191±87ml, 800±265mg, and 500±214 mg, respectively.
