Abstract
The effect of lipid peroxides on microtubule assembly was investigated. Microtubule formation from bovine brain tubulin was inhibited dosedependently by lipid hydroperoxides produced from commercial lecithin by photooxidation. This indicates the possibility of in vivo interaction of tubulin with lipid peroxides. Thus, it is possible that this interaction may be a cause of some brain diseases, based on observations of the cytoskeleton in Alzheimer's disease, and the hypothesis that the microtubule system is damaged in this disease.
