We report a case of multiple myeloma with initial symptoms of amyloidosis of the tongue and buccal mucosa. A man in his 60s complained of glossalgia and hypogeusia at initial presentation; general fatigue and dyspnea were also present. Nodular masses with large and small areas of induration were scattered on the dorsum of the tongue. On the basis of biopsy findings, a pathological diagnosis of amyloidosis was made. For the patient’s systemic symptoms, the internal medicine department was consulted. Reduction in the levels of IgG and IgA was observed, and according to findings on bone marrow biopsy, a diagnosis of multiple myeloma was made. However, the patient’s cardiac and respiratory function deteriorated; he suddenly developed VF and died. Our findings suggest that in case of a refractory ulcer or mass lesion on the tongue, it is necessary to consider the possibility of systemic diseases to ensure accurate diagnosis and timely treatment for the patient.
