Among tumors appearing commonly on the limbs, angiolipomas are frequent in the forearms, but relatively rare in the head and neck region. Here, we report a case of an infiltrating angiolipoma of the cheek. The patient was a 55-year-old male who presented with the chief complaint of right-sided cheek swelling. He visited our department due to cheek swelling in May 201X. Although the tumor border was indistinct from a computed tomography （CT） artifact, the border and neighboring tissues were clear on short-T1 inversion recovery （STIR） cystography magnetic resonance imaging （MRI）. Additionally, biopsy revealed the presence of multiple phleboid blood vessels in mature adipose tissues. Subsequently, the tumor was resected by intraoral incision, and the pathology results identified an infiltrating angiolipoma. A capsule was not present in the tumor, which revealed significant vascular endothelial growth factor （VEGF） levels in the muscular gap upon immunostaining. We judged the addibility of this tumor to be very high. Two years after surgery, we have not observed tumor recurrence and the patient’s prognosis has remained good.
