右頰粘膜腫瘤を契機として診断されたマントル細胞リンパ腫の1例

抄録

Mantle cell lymphoma is a rare lymphoma of B-cell origin characterized by a poor prognosis. We report a case of mantle cell lymphoma diagnosed in a mass of the right buccal mucosa as a primary symptom.
A woman in her 70s consulted a dental clinic because of right buccal mucosa caused by accidental biting of the buccal mucosa. After one month, she was referred to our hospital because her buccal mucosa had not changed. We performed occlusal adjustment based on her clinical history, but no improvement was found, so we performed a biopsy. As immunohistochemistry, the biopsy material was positive for CD20, CD79a, CD5, BCL2, CyclinD1, and negative for CD10, CD23, CD56, and CD3, so we made a diagnosis of MCL. After being treated with R-CHOP therapy at our hospital hematology department, she has been treated with maintenance therapy by rituximab, and continues to be followed.
Because patients with mantle cell lymphoma very often have no subject symptoms, approximately 90％ are already at stage Ⅲ to Ⅳ. One reason why mantle cell lymphoma has a poor prognosis is that the diagnosis is made at a late stage.
We suggest that the treatment of mantle cell lymphoma can be improved by performing immediate biopsy.