抄録
Boneject® is a powdered bone filling substance consisting of atelocollagen solution and natural hydroxyapatite prepared from bovine bones.
Implants were placed in 15 patients and Boneject® was concurrently applied to implant sites lacking sufficient alveolar bone. Postoperatively, the sites applied Boneject® were studied clinically and pathologically. The type of Boneject® used was KF300, with a particle diameter of 300 to 600 μm.
Postoperative evaluations were performed by roentgenographic examination and clinical examination, including assessment of the status of wound healing. The hardness of the region filled with Boneject® was tested by test puncture with an engine reamer at the time of secondary operation. In addition, tissue samples were taken from the filled region in 10 patients and were examined under alight microscope.
The results were as follows:
1. After the operation, there were no distinct signs or symptoms of infection or poor wound healing in any patient.
2. By roentgenographic examination, increased radiolucency was seen in 3 patients after 6 months. In addition, 2 patients showed evidence of partial absorption at the filled site. No patients showed increased radiopacity.
3. Puncture tests could be performed at 10 sites. The filled sites were relatively soft in many patients, even during secondary operation.
4. Pathological examinations were performed in 10 patients. Evidence of osteogenesis between the Boneject® particles was found in all of these patients. In 3 patients, bone had formed between almost all particles, and there was good fusion between newly-formed bone and the Boneject® particles. No patient had any findings of inflammation or reaction to a foreign substance.
The amount and rate of new bone formation at the sites filled with Boneject® did not necessarily correlate with clinical or roentgenographic findings. It is considered that biopsy specimens of bone should be examined to evaluate the state of osteogenesis at sites applied Boneject®.
