日本口腔インプラント学会誌
原著
多血小板血漿(PRP)による骨形成促進に関する実験的研究
―新生骨形成の初期過程の検索―
田辺 俊一郎松田 成彦山本 正剛永山 元彦永原 國央
著者情報
ジャーナル フリー

18 巻 (2005) 4 号 p. 533-539

詳細
PDFをダウンロード (2711K) 発行機関連絡先
抄録

The bone augmentation method for dental implants has become a main means of controlling the prognosis of dental implants in clinical treatment. Platelet-rich plasma (PRP) has been accepted as a safe material which can be extracted from the blood of patients. Furthermore, PRP is used in many treatments to enhance bone formation.
The aim of this study was to identify what kind of growth factor was affected by PRP on bone formation in an animal experiment.
Six adult dogs were selected, and four implants were placed in the lower jaw of each dog; two implants were located on the right side and the other two on the left side, to obtain control and experimental sides respectively. After that, an artificial bony defect was made between two implants on both sides, and then the defect on the experimental side was filled up with PRP extracted from the same dog. Radiographic, histological and immunohistochemical methods were used for a comparative analysis.
The results showed new bone formation due to PRP at the first week after the operation, and it was identified by both radiographic and histological methods. In addition, positive reactions of PDGF in immunohistochemical qualitative analysis and quantitative search were confirmed.
From the data it was concluded that PDGF was the main growth factor for the bone formation when PRP was applied to the artificial bony defects of the studied dogs.

著者関連情報
© 2005 公益社団法人日本口腔インプラント学会
前の記事 次の記事

閲覧履歴
feedback
Top