抄録
In this study, evaluation using experimental animals was conducted to determine whether or not a method combining dehydrothermally (DHT) cross-linking collagen sponge hybridized with autologous periosteum and DHT cross-linking collagen-coated lactic acid-glycolic acid copolymer membrane (C-PLA membrane) would be effective in the GBR method as a means of performing intraosseus implantation in an edentulous area with a dehiscence-type bone defect. The edentulous area of the mandible of beagle dogs was used as the experimental site, and the new bone forming function was evaluated histopathologically 8 weeks postoperatively. The results showed significant increases in the height and the area of the new bone formation in the experimental group compared with the control group (C-PLA membrane group). The change with time showed a significant increase in new bone formation from 4 to 8 weeks postoperatively compared with from 2 to 4 weeks postoperatively. No difference was found between the groups in regard to the standard nature of the bone defects, and the C-PLA membrane was confirmed to be present in all of the animals. The above findings suggested that this method will be useful in the GBR method of treating local bone defects.
