Distribution of fleroxacin (FLRX) into serum and oral tissues

Abstract

This study inestigates the distribution of fleroxacin (FLRX) in 23 patients after 3 hr, 4 hr, 6 hr, 12 hr, and 24 hr following the oral administration of 300 mg FLRX.
The peak concentrations in serum, gingiva and mandibular bone observed 6 hr after administration appeared to be 4.05 μg/ml, 8.13μg/g and 0.73 μg/g, respectively.
The ratio of concentration of FLRX gingiva and in mandibular bone to that in serum were 1.99±0.59 and 0.19±0.07 respectively.