口腔外科領域における小手術後患者を対象としたSuprofen (TO-177) の二重盲検比較試験

抄録

A multi-center double-blind study in comparison with aspirin was conducted to evaluate the effectiveness, safety and usefulness of Suprofen (TO-177), a new non-steroidal analgesic/anti inflammatory agent, in tooth extraction of mandibular impacted wisdom tooth.
Patients were treated with Suprofen (SP) 100mg three times a day or aspirin (AP) 500mg three times a day.
The results were obtained as follows.
1) Total treated cases were 272 (SP: 133 cases, AP: 139 cases) . 4 cases were excluded.
2) According to the clinical efficacy, the ratio of“good or better”was 74.4% with SP group and 61.2% with AP group. There was a significant difference between two groups (p<0.001) .
3) Side effects were reported 3 cases (2.3%) SP group and 10 cases (5.1%) AP group.
4) In the general utility rating, the ratio of“useful or better”was 72.7% with SP group and 56.7% with AP group. There was a significant difference between two groups (p<0.001) .
The results indicate that Suprofen is a safe and useful anti inflammatory analgesic agent.