巻号一覧
2 巻 (1983)
- 2 号 p. 71-
- 1 号 p. 1-
2 巻, 1 号
選択された号の論文の8件中1～8を表示しています
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高井 宏, 西山 和彦, 阿部 裕哉, 三科 正見, 沼倉 博人, 宮奈 秀夫, 鈴木 博保1983 年 2 巻 1 号 p. 1-13
発行日: 1983/06/30
公開日: 2010/06/08
ジャーナル フリー“Inteban ointment”contained a non steroidal anti-inflammatory agent of indomethacin, was used to 36 patients of mandibular arthrosis without any other treatment.
The application method of the ointment was that 5 to 8g of them for one day were divided to 4 times, and rubbed in tempolo-mandibular joint region after meals and before sleep.
The evaluation of the clinical efficacy was judged by score method that each symptoms of mandibular arthrosis were given the standardized score by the severity, compared and analysed with statistically the score of first day, 7th day and 14th day from the start of application.
The results obtained were as follows:
1. Average score of the first day 10.58 was improved to 6.39 at 14th day, showing a significant difference (p<0.001, t-test) .
2. The symptoms show the remarkable improvements were oppressive pain on tempolomandibular joint region, and spontaneous pain at mandibular movement.
3. Side-effect was not recognized in this series.抄録全体を表示PDF形式でダウンロード (1120K) -
松崎 輝宏1983 年 2 巻 1 号 p. 14-19
発行日: 1983/06/30
公開日: 2010/06/08
ジャーナル フリー抗生物質として, 点滴静注を適応とするcefemcをとりあげ, CTZ, CEZ, CET, CERおよびCEPRについて菌と抗生物質の接触時間を1時間と3時間に限定して, 菌の発育増殖抑制時間を測定した.試験菌はS.aureus 209P株, また測定機器は東洋科学製のbiorecorderでshakingしながら連続測定した.
菌と抗生剤の接触が1時間のときには, CERは1.56μg/mlで6時間の増殖遅延がみられるのに, 他の4剤では濃度を6.25μg/mlまで増量しても, 増殖遅延時間が5時間を越すことはなかった.菌と抗生剤の接触が3時間のときには, 1.56μg/mlでCERは15時間以上の増殖遅延を示し, CEPRでも12時間の遅延がみられた.他の3剤では1.56μ/mlで5.4～6.6時間の増殖遅延であり, 6.25μg/mlになると, CETでは13時間以上の増殖遅延を示すが, CTZとCEzは7.2～7.6時間の増殖遅延で, 1.56μg/mlの場合と大きな差はなかった.抄録全体を表示PDF形式でダウンロード (590K) -
安本 龍生, 末永 忠博, 田中 重喜, 野坂 嵩1983 年 2 巻 1 号 p. 20-23
発行日: 1983/06/30
公開日: 2010/06/08
ジャーナル フリーMyoactin C, which was used for alveolar pyorrhea, is composed of ATP, L-tyrosine and L-cysteine, as fix combination drugs.
The author observed that ATP increased the tone of smooth muscle at a low concentration, and decreased it as a high concentration on the mechanical activity of the smooth muscle (portal vein), but the effects of Myoactin C on the smooth muscle can be considered that they relate closely with L-tyrosine, +L-cysteine, +ketoglutaric acid.抄録全体を表示PDF形式でダウンロード (372K) -
中村 仁也, 塩谷 泰宏, 伊藤 努, 山城 三喜子, 古屋 英毅1983 年 2 巻 1 号 p. 24-28
発行日: 1983/06/30
公開日: 2010/06/08
ジャーナル フリーIn the dental treatment of hypertensive patients, we applied nifedipine, which reliable and mild effects are expectable, and obtained good results.
The subjects used are 10 hypertensive patients categorized as the stage I and II of WHO classification who visited our hospital for tooth extraction. The ages of patients ranged from 54 to 76 years old.
Local anesthesia with 2% lidocaine containing 1/80, 000 epinephrine was applied 20 min after sublingual administration of 10mg of nifedipine. Then, 10 min later, blood pressure, mean blood pressure and pulse rate were measured.
Both systolic and diastolic pressures started to decline 5 min after the administration of nifedipine, reached the minimum level after 20 min and stayed at that level until 60 min after the administration.
Pressor effect due to the local anesthesia and tooth extraction was mild, and hemodynamics was kept stable. Also, neither dizziness nor body sway was observed.抄録全体を表示PDF形式でダウンロード (475K) -
松崎 輝宏1983 年 2 巻 1 号 p. 29-36
発行日: 1983/06/30
公開日: 2010/06/08
ジャーナル フリーCefemsとS.aureusをbiorecorderで37℃でshakingしながら一定時間接触させた後, Cepha-losporinaseを加えて, そのままshakingしながら培養を続けて菌の発育増殖抑制時間を測定検討した.
実験1.実験に用いたCefemsはcephalosporinase 290 units/mlによってantimicrobial activityを失うことを確認した.
実験2.Cefems 6剤とS.aureus 209Pを3時間接触させた後, Cephalosporjnaseを加え培養を続けてdelayed growth timeを測定した.0.78～6.25μg/mlについて考察すると長いものよりCEPR≧CER≧CTZ>CPZ>CET>CEZの順になった.また各cefemsにはdose dependenceがあることがわかった.
実験3.S.aureus 209Pと臨床分離のS.aureus 3株を用いCERとの接触を3時間として実験を行った結果delayed growth timeは菌株によって差があることがわかった.
実験4.実験3の菌株を用いCERとの接触を2, 3, 4時間として実験を行った結果delayed growth timeはtime dependenceがあることがわかった.
実験5.経口用CEX, CDXを用い接触時間を3.5時間としてdelayed growth timeを測定した結果1.56～6.25μg/mlの間においてCDXのほうがCEXより長いことがわかった.抄録全体を表示PDF形式でダウンロード (785K) -
石橋 克禮, 浅田 洸一, 橋本 房三, 久野 吉雄, 佐藤 田鶴子, 山田 隆久, 志村 介三, 鎌田 仁, 佐々木 次郎, 植松 正孝, ...1983 年 2 巻 1 号 p. 37-50
発行日: 1983/06/30
公開日: 2010/06/08
ジャーナル フリーA multi-clinic double-blind study was conducted to examine the analgesic efficacy and safety of Suprofen, a new non-steroidal anti-inflammatory agent, in comparison with indomethacin after tooth extraction. Patients were administered either Suprofen 200mg or indomethacin 25mg.
1. Statistically analyzed cases were 101 with Suprofen group and 106 with indomethacin group, 207 as total. Drop out and excluded cases were 5 with Suprofen group and 7 with indomethacin group.
2. In global improvement rating of a pain and overall clinical evaluation, Suprofen group was significantly superior to indomethacin group (ρ<0.01) .
3. In time till appearance of effect, Suprofen group was significantly faster to indomethacin group (ρ<0.01) .
4. Side effects were reported 7 cases in Suprofen group and 5 cases in indomethacin group, and no significantly differences were shown between the two groups.
Summarizing the above results, it can be concluded that Suprofen is a useful drug after tooth extraction and that analgesic efficiency and safety on Suprofen administration were better than indomethacin administration.抄録全体を表示PDF形式でダウンロード (1355K) -
高井 宏, 池嶋 一兆, 大村 光, 道 健一, 斉藤 健一, 大野 康亮, 関山 三郎, 結城 勝彦, 瀬川 敦義, 酒泉 和夫, 永井 ...1983 年 2 巻 1 号 p. 51-62
発行日: 1983/06/30
公開日: 2010/06/08
ジャーナル フリーA multi-center double-blind study in comparison with aspirin was conducted to evaluate the effectiveness, safety and usefulness of Suprofen (TO-177), a new non-steroidal analgesic/anti inflammatory agent, in tooth extraction of mandibular impacted wisdom tooth.
Patients were treated with Suprofen (SP) 100mg three times a day or aspirin (AP) 500mg three times a day.
The results were obtained as follows.
1) Total treated cases were 272 (SP: 133 cases, AP: 139 cases) . 4 cases were excluded.
2) According to the clinical efficacy, the ratio of“good or better”was 74.4% with SP group and 61.2% with AP group. There was a significant difference between two groups (p<0.001) .
3) Side effects were reported 3 cases (2.3%) SP group and 10 cases (5.1%) AP group.
4) In the general utility rating, the ratio of“useful or better”was 72.7% with SP group and 56.7% with AP group. There was a significant difference between two groups (p<0.001) .
The results indicate that Suprofen is a safe and useful anti inflammatory analgesic agent.抄録全体を表示PDF形式でダウンロード (1009K) -
坂本 春生, 宮地 繁, 森鼻 健史, 高崎 謙治, 佐々木 次郎, 斉藤 博, 中村 一賀1983 年 2 巻 1 号 p. 63-67
発行日: 1983/06/30
公開日: 2010/06/08
ジャーナル フリー高速液体クロマトグラフィー (HPLC) を用い, cephalothin (CET) および, 代謝物desacetyl-cephalothin (DACET) のヒト血清中濃度を分離定量したところ, 従来からのbioassayの結果とよく相関した.
さらに慢性腎不全にて人工透析中の患者4名を対象として, CET投与後のCET, および, DACETの血清中濃度を分離定量した結果, 健常人にみられるような, DACETの経時的な減少傾向を示さず, 量が多く, 個人差の大きいことがわかった.
また, HPLCは, bioassayに比較し, きわめて短時間に, 分離定量が可能であった.抄録全体を表示PDF形式でダウンロード (471K)
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