抄録
Flomoxef sodium (FMOX) was examined for its fundamental property in tissue concentration and antibacterial potency. The following results were obtained.
1. The tissue concentrations of FMOX after one hour intravenous injection were 14.7±1.8 μg/ml, 8.5±2.1 μg/g and 4.0±3.1 μg/g in serum, gingiva and jaw, respectively.
2. The rates of bacterial disappearance were judged by measuring 75 clinically isolated strains. Eighty percents of minimum inhibitory concentration (MIC80) on 47 strains of aerobic bacteria was 6.3 μg/ml. MIC80 on 28 strains of anaerobic was 1.6 μg/ml.
3. The tissue concentrations measured on serum and gingiva were higher than that of MIC80 clinically isolated 75 strains. From these results, FMOX is considered to be able to prevent bacterial growth in oral infections.
