歯科薬物療法

口腔外科領域の各種急性感染症に対するFlomoxef sodium (FMOX) の臨床的検討

中島正晴, 高塚茂行, 西出雅博, 村上圭司, 児島伸也, 野尻孝司, 岡部孝一, 馬場利人, 加藤隆三, 松原完也, ...

1990 年 9 巻 2 号 p. 73-78
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.73

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Clinical studies of FMOX in various infections in the field of oral surgery were carried out. FMOX was administered by intravenous injection to 21 patients who suffered from oral and mxillo-facial infection and to 20 other patients for preventing post-operative infection. The following results were obtained:
1) Effective rate in subjective judgement was 100% in the group of both once-a-day dosing and twice-a-day dosing. Effective rate in judgement by point was 92.3% in the group of once-a-day dosing, 100% in the group of twice-a-day dosing.
2) No side effect was observed in any cases.
3) The results indicated the usefulness of FMOX in the treatment of various infections in the field of oral surgery.

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口腔外科領域におけるFlomoxef sodium (FMOX) の基礎的検討

高塚茂行, 中島正晴, 西出雅博, 村上圭司, 児島伸也, 野尻孝司, 岡部孝一, 馬場利人, 加藤隆三, 松原完也, ...

1990 年 9 巻 2 号 p. 79-84
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.79

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Flomoxef sodium (FMOX) was examined for its fundamental property in tissue concentration and antibacterial potency. The following results were obtained.
1. The tissue concentrations of FMOX after one hour intravenous injection were 14.7±1.8 μg/ml, 8.5±2.1 μg/g and 4.0±3.1 μg/g in serum, gingiva and jaw, respectively.
2. The rates of bacterial disappearance were judged by measuring 75 clinically isolated strains. Eighty percents of minimum inhibitory concentration (MIC₈₀) on 47 strains of aerobic bacteria was 6.3 μg/ml. MIC₈₀ on 28 strains of anaerobic was 1.6 μg/ml.
3. The tissue concentrations measured on serum and gingiva were higher than that of MIC₈₀ clinically isolated 75 strains. From these results, FMOX is considered to be able to prevent bacterial growth in oral infections.

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アンフェナクナトリウムの臨床評価ジクロフェナクナトリウムとの比較試験

中西誠, 水川展吉, 小山茂樹, 高木慎, 西嶋克巳

1990 年 9 巻 2 号 p. 85-92
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.85

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The therapeutic effects of Amfenac sodium (50mg) were compared with those of Diclofenac sodium (50mg) on postexodontic pain. The following results were obtained:
1) The analgetics were treated for 102 patients with pain after extraction of wisdom tooth. 47 cases were treated with Amfenac sodium (A group) and 55 cases were treated with Diclofenac sodium (D group) .
2) There was no statistically significant difference between the two groups for the back ground parameters considered.
3) According to both the doctor's and the patient's judgement of the pain improvement rating, there was no significant difference between the two groups.
4) According to a numerical judgement, in the pain improvement rating and time until the appearance of effect after administration, the A group was significantly superior to the D group.
5) There was no significant difference between the two groups in duration of successive effect after administration.
6) There was no significant difference between the two groups in total effects and side effects and total usefulness.

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遠赤外線の組織培養用プラスチック製シャーレに対する透過性について

松本章, 久田洋, 久光久, 東光照夫, 和久本貞雄

1990 年 9 巻 2 号 p. 93-95
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.93

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We examined the transmittance of FIR on 35mmφ plastic petri dish for tissue culture
The transmittance was 18% at 8.87μm, 10% at 11.5, 12.2 and 15.5μm.
From these results, it was found that although the transmittance was low, FIR could transmit the plastic petri dish, and it was suggested thet FIR exactly affected the functions of tooth germs.

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急性歯性感染症に対するBMY-28100の臨床評価

Cefaclorを対照とする二重盲検比較試験

佐々木次郎, 森鼻健史, 植松正孝, 椎木一雄, 山根伸夫, 菅野直美, 坂本春生, 森島丘, 重原聡, 佐藤田鶴子, ...

1990 年 9 巻 2 号 p. 96-112
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.96

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The clinical usefulness of BMY-28100, a new oral cephem antibiotic, was compared objectively with that of cefaclor (CCL) using a double-blind method in the department of orofacial odontogenic infections.
A total of 190 patients were administered with the test substances (BMY-28100 and CCL), and the clinical efficacy of 84 patients in the BMY-28100 group and of 83 patients in the CCL group was evaluated. Efficacy rate as evaluated by the score method was 83.3% in the BMY-28100 group and 85.5% in the CCL group.
Efficacy rate as evaluated by the investigators was 82.1% in the BMY-28100 group and 84.3% in the CCL group. The differences between the 2 drug groups were not statistically significant. The organisms were isolated in 64 patients (30 in the BMY-28100 group and 34 in the CCL group), and the difference between the 2 drug groups in these patients was also not statistically significant.
Adverse reactions were observed in 1 patient in the BMY-28100 group and in 4 patients in the CCL group, while abnormal laboratory findings were observed in 2 patients (3 cases) in the BMY-28100 group and in 3 patients (3 cases) in the CCL group. None of these differences was statistically significant.
The usefulness rates were almost the same for the 2 drug groups.
The results indicated that BMY-28100 was almost equal to CCL in utility evaluations in the treatment of orofacial odontogenic infections.

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Cefteram pivoxil (CFTM-PI) 多施設臨床試験の分離菌株に対する細菌学的検討

金子明寛, 椎木一雄, 坂本春生, 佐藤田鶴子, 道健一, 大曽根洋, 近内寿勝, 山本忠, 服部孝範, 杉村正仁, 藤 ...

1990 年 9 巻 2 号 p. 113-122
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.113

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Bacteriological studies were carried out in the field of oral and maxillofacial surgery. The total number of isolated organisms were 164 species. The results were as follows.
1. Gram-positive bacteria were isolated from the oral infections using high frequency.
2. Oral streptococci were the major isolates and S. anginosus, S. interntedius and S. constellatus were isolated individually.
3. The anaerobes were isolated mainly from mixed infections.
Especially anaerobic gram-negative bacteria tended to be isolatded from the osteitis of jaw.
4. The MIC for 80% of organisms of CFTM, CCL and ABPC were 0.05, 1.56 and 0.025μg/ml against Oral Streptococci.
5. Judging from Cmax/MIC and the above MIC, CFTM and ABPC were acceptable for first choice.

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気化した根管消毒剤の培養細胞に対する影響について

小森規雄, 羽根田高洋, 武市収, 宮田泰, 服部嘉郎, 久保和彦, 山口和男, 目澤修二, 若松佳子, 齋藤毅

1990 年 9 巻 2 号 p. 123-127
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.123

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The purpose of this study is to evaluate the cytotoxic effect of the vaporized root canal medicament on cultured cells.
The cultured cells used in this study were fibroblasts originated in subcutaneous connective tissue of the rat (L-181) and the root canal medicament used was formocresol (FC, Neo Dental chemical Products Co. LTD) .
The cells were grown to monolayers on dish bases, and then were exposed to vaporized FC by means of modified tube method.
24 hours after cell-FC contact, the vaporized FC and tube were removed and the medium tissue was changed.
The cell numbers were counted by Coulter Counter and morphologically observed using scanning electron microscopy and phase contrast microscopy every 24 to 72 hours after medium was changed.
The results obtained were as follows:
1. Cell growth was seriously inhibited by vaporized formocresol.
2. After cell-formocresol contact for 24 hours, cytotoxic effect continued for 72 hours, even if the vaporized formocresol was removed and the medium was changed.
3. Morphological observation showed cell damage indicating noticeable constriction.

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全麻覚醒時の著しい血圧上昇に対する塩酸ニカルジピン (ペルジピン) の降圧効果

鮎瀬卓郎, 伊藤弘通, 久保田康耶

1990 年 9 巻 2 号 p. 128-132
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.128

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Hypertension is frequently encountered during the emergence of general anethesia, caused by the stimulation of endotracheal tube, drug withdrawal, pain and so on.
In order to prevent this hypertension during the emergence period, nicardipine hydrochloride (0.01mg/kg to 0.02mg/kg) was administrated to twenty-two paients.
The effect of nicardipine was reduction of blood pressure and the rate pressure product was obtained within 5 minutes and significant.
These results indicate that the rapid and strong antihypertensive effect of nicardipine is useful and safe for the treatment during the emergence of general anethesia.

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フィブリン接着剤 (Tisseel-kit) の口腔疾患への使用経験

岡田隆, 大野康亮, 秋月弘道, 斎藤健一, 吉田広, 道健一

1990 年 9 巻 2 号 p. 133-137
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.133

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Our experience with the use of a fibrin adhesive (Tisseel^®-Kit) in oral surgery is reported.
Tisseel^®-kit is a biological tissue adhesive consisting of highly concentrated human fibrinogen. thrombin and factor XIII.
We applied Tisseel^®-Kit in 19 cases of various oral surgical operations in the oral surgery including adhesive fixation of isolated skin graft, pedicled ucosal flap and lyophilized porcine skin.
The clinical results were good in 17 cases, and fair in 2 cases.
The side effects were not observed in any of the cases in which the fibrin adhesive was employed.
The results indicate that Tisseel^®-Kit is useful for oral surgery.

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糖尿病患者にみられた難治性感染症の一治験例

斎藤健一, 森紀美江, 秋月弘道, 吉田広, 道健一

1990 年 9 巻 2 号 p. 138-142
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.138

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The diabetic state is said to decrease host resistance to infection.
A case of a severe oral infection in a 58-year-old male with diabetes mellitus was reported. An usual treatment which was tooth extraction after adminstrating antibiotics was not effective for this case because of the savere condition of his diabetic state.
After consulting with his physician about the administrated volume of insulin, we corrected the volume of his insulin.
Since, the value of FBS was got about 140mg/dl, we performed a removal operation of inflammatory lesion in extraoral approach. As a result, the infectious lesion of the patient diminished.
It is important in the treatment of infectious patient with diabetes mellitus to control their blood sugar.

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レンサ球菌の新しい分類に対する本邦臨床検査の現状

佐々木次郎, 金子明寛, 江端洋, 出口浩一

1990 年 9 巻 2 号 p. 143-147
発行日: 1990/08/01
公開日: 2010/06/08

DOIhttps://doi.org/10.11263/jsotp1982.9.143

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Since the publishment of Bergey's Manual of systematic Bacteriology in 1986, Streptococcus anginosus, S. constellatus, S. intermedius and S. milleri were classified in the Streptococcus milleri group. This classification has been used in Japan and all over the world.
This time S. milleri group has to be classified according to the hybridization method into sole S. anginosus, From the aspect of clinical bacteriology in Japan, there are differences among S, anginosus, S. constellatus, S. intermedius and S. milleri in MIC_s of various antimicrobial agents. In these standpoints Bergey's classification of Streptococcus milleri group is still useful for us.

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