Navigating pediatric renal tumors: A historical overview of clinical research and practical insights

Abstract

Pediatric renal tumors, with Wilms tumor (nephroblastoma) being most prevalent, hold significant clinical importance. This article aims to provide a succinct overview of the historical progression in clinical studies, treatment milestones achieved so far, and contemporary treatment strategies, primarily focusing on Wilms tumor. Additionally, owing to its didactic nature, this paper incorporates insightful commentaries and educational lectures accompanying each chapter to enhance its applicability to real-world clinical scenarios. This paper, which presents a brief history of clinical research with practical articles, will help us deepen our understanding of pediatric renal tumors. Although the recently initiated Umbrella protocol holds intricate details that must be perused by study participants, its ongoing implementation promises to propel biological research to new heights. With this, I encourage the utilization of the knowledge herein for effective clinical practice starting from the immediate future.