患者のQOL(Quality of Life)向上を目指したパップ剤の有用性

抄録

Cataplasm containing anti-inflammatory and analgestic drug, ketoprofen, was developed. Cataplasm containing ketoprofen features the cross-linking network between aluminum and sodium polyacrylate and is a swollen hydrogel. Cataplasm can contain large amount of drug, water and other additives. Ketoprofen dispersed as microemulsions in the cataplasm is easily released from cataplasm and absorbed into the skin. Adhesion properties between cataplasms and between cataplasm and hairless mice skin were evaluated using phosphor-bronze thin plate technique. Skin-cataplasm adhesion force and cataplasm-cataplasm separation force are in good agreement with human sensory test. The diseased part was also cooled and moistured by cataplasm. It was found that cataplasm containing ketoprofen is a friendly formulation for patients.