This paper introduces our studies of the topology and dynamics in biological molecules (i.e. lipids and proteins) observed using atomic force microscopy (AFM). Samples for observation were adsorbed on hydrophilic mica and nanofabricated silicon substrates. Topological information about proteins enabled us to understand their physiological mechanisms and biophysical properties. Lipid bilayers were successfully formed on a solid substrate and could be used as an interface between proteins and substrates.
