抄録
There is marked advancement in transplant therapy. In particular, progress in immunosuppressants has especially improved graft success dramatically. However, the rate of malignant tumor generation and morbidity in regard to postrenal transplants are notably increasing. Compared to the mechanism whereby malignant tumors are generated in healthy adults, exposure to immunosuppressants and viral infections are involved in the generation of malignant tumors postrenal transplant and thus has a different aspect. Compared to the West, digestive organ cancers were the malignant tumors commonly generated in Japan. However, recent reports from various countries state that the rates at which skin cancer and posttransplant lymphoproliferative disorders are generated have increased at the same level as they have in the West. The appearance of mTOR inhibitors is expected hereafter to produce change in the rate of malignant tumor generation. However, restraint of excessive immune suppression, viral infection control, and postoperative control by screening tests have at least improved treatment results of malignant tumors. Moreover, this is linked to improvement in long-term results in renal transplants.
