Platelets stimulate liver regeneration in a rat transplantation model
2020 年 55 巻 Supplement 号 p. 341_3
詳細
2020 年 55 巻 Supplement 号 p. 341_3
Liver transplantation (LT) is related to liver regeneration and ischemia-reperfusion (I/R) injury. The aim of our study is to identify the role of platelets after partial LT.We used a 30% partial LT rat model, and used thrombopoietin (TPO) to increase platelet levels.The serum levels of AST, ALT and TBIL decreased significantly in the TPO group. The regeneration-related factors were significantly higher post-LT in the TPO group, and the apoptosis pathways had no change.Our results indicate that platelets stimulate liver regeneration without aggregating I/R injury after partial LT in rat.
