抄録
Two hepatotropic viruses, i.e. mouse hepatitis virus isolated by Buescher' and Ectromelia virus, were inoculated into mice intraperineally and histopathological changes of mice were pursued with particular emphasis on the features of the liver.
In addition to these studies, the level of liver glycogen and blood sugar of mice was estimated day by day after infection. One of the hepatotoxic substance, toyocamycin, which has been isolated in our laboratory from a streptomyces filtrate, was also tested just for comparison. The results obtained in such studies are the subject of this communication and will be summarized as follows:
1). All of the mice injected with two different viruses and toyocamycin died almost within 72hrs. On the histopathological examination, conspicuous changes were chiefly limited to the liver. These changes were characteristic with each agent.
2) Both the suger content of the blood and liver glycogen decreased gradually after inoculation of the above two viruses. However, with toyocamycin injection, liver glycogen decreased without any detectable changes of blood sugar content.
3). When glucose tolerance test was employed, the drop down of reserve activity of liver glycogen have been recongnized with these three groups.
4). In glucose tolerance test, administration of dl-methionine or glucuronic acid, particularly the latter, was favourable for improving the liver function with toyocamycin injected mice, but no effect was observed with the mice infected with viruses.
From the above observation, the auther concluded that with viral hepatitis, low blood sugar content would be partly explainable with lowered activility of liver function, but the disorders in other parts of body, which would participate in controlling the blood sugar level should be also considered. On the other hand, toxicity of toyocamycin was rather limited to the liver.
